The art of hold down is a lot like the art of setting concrete forms. Too little and the project is ruined. Too much and the setup/teardown process is too arduous and time consuming. What you want is the goldilocks zone of hold down.
Before deciding on your hold down, you should understand the forces that the machine will exert on the workpiece. A good rule of thumb is that the bigger the end mill, the more forces are involved. So if you're using a 1/8" end mill, then your hold down is minimized.
Feeds and speeds impact the forces too, so if you're not in a hurry, using slower speeds will reduce the side loads and allow for less hold down.
The type of bit also influences the hold down requirements. An upcut end mill will try to pull the workpiece off the machine, while a downcut will push down on the piece. Cutting thin material without a vacuum would be a trick with an upcut. V-bit's have no pull or push on the piece so if you're using one of these, all you need to do is stop sideways movement.
For thick pieces, I typically will use an edge clamp on at least two places and then block the sides with scraps of wood. Block all sides. The key thing is to stop any movement from starting so if your hold down is weak in one direction and the piece starts moving, it won't stop until it's thrown off the table or the bit breaks. So keep your hold down jigs tight so there's not the slightest wiggle.
To tell if your piece is down tight, tap on the corners of the piece and listen for a hollow sound. That means the piece isn't firmly attached to the machine and will likely wiggle and break free.
Be wary of steel clamps and bolts that may be in the path of the endmill. While the bit can probably chew through the edge of your aluminum clamp, it will break the millisecond it touches steel. So steel is bad. Wood, plastic, aluminum good.
Hold down is a topic that's both wide and deep and the best way to learn is to try different methods.
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